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    by: KULDEEP

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    1 : A Seminar on melatonin hormone Presented By- Kuldeep Kinja M Pharma 2nd Yr Pharmacology
    2 : Melatonin also known chemically as N-acetyl-5-methoxytryptamine. Is a naturally occurring compound found in animals, plants, and microbes. In animals,circulating levels of the hormone melatonin vary in a daily cycle. Allowing the entrainment of the circadian rhythms of several biological function . It produced in the pineal gland which is outside of the blood-brain barrier acts as an endocrine hormone since it is released into the blood melatonin produced by the retina and the gastrointestinal (GI) tract INTRODUCTION
    3 : Many biological effects of melatonin are produced through activation of melatonin receptors powerful antioxidant, with a particular role in the protection of nuclear and mitochondrial DNA Known as the "hormone of darkness", it is secreted in darkness in both day-active (diurnal) and night-active (nocturnal) . It may also be produced by a variety of peripheral cells such as bone marrow cells, lymphocytes and epithelial cells.
    4 : HISTORY
    5 : Melatonin receptors Found in central nervous system and peripheral tissues In brain MT1 AND MT2 receptors are found in membranes of neurons of (SCN). MTI AND MT2 are G-protien-couple receptors. MT3 receptor is also found which is poorly understood.

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