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    Add as FriendThe Truths and Myths of Alzheimer Disease

    by: George

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    1 : Remembering for those who canNOt: the truths and myths of alzheimer disease George Perry, Ph.D. Dean and Professor Semmes Foundation Endowed Chair in Neurobiology
    2 : Myths of AD Myth: Memory loss is a natural part of aging. Reality: In the past memory loss was considered a normal part of aging. Experts now recognize severe memory loss as a symptom of serious illness. Whether memory naturally declines to some extent remains an open question.
    3 : Myths of AD Myth: Alzheimer's disease is hereditary. Reality: Rare cases of early-onset AD affects people in their 30s, 40s, and 50s. The more common late-onset AD usually affects people over the age 65. The greatest risk factor for developing late-onset AD is increasing age. Researchers have found one gene that is associated with increased risk of late-onset AD.
    4 : Myths of AD Myth: Alzheimer's disease is not fatal. Reality: Alzheimer's is a fatal disease. It begins with destruction of cells in regions of the brain that control memory. Eventual loss of cells in other regions of the brain leads to failure of other essential systems in the body. Because many people with AD have other old-age illnesses, the actual cause of death may be no single factor.
    5 : Myths of AD Myth: Head injury can lead to Alzheimer's disease. Reality: Several studies have found that AD is more common among those who have sustained a severe head injury with loss of consciousness. Additional research is needed to understand the effect of such injuries on the brain and how that may relate to AD.
    6 : Myths of AD Myth: Drinking out of aluminum cans or cooking in aluminum pots and pans can lead to Alzheimer's disease. Reality: The exact role (if any) of aluminum in AD is still being researched and debated. Most researchers believe that not enough evidence exists to consider aluminum a risk factor for AD or a cause of dementia.
    7 : Myths of AD Myth: There are therapies available to stop the progression of Alzheimer's disease. Reality: At this time, there is no medical treatment to cure or stop the progression of AD, Four FDA-approved drugs — tacrine (Cognex®), donepezil (Aricept®), rivastigmine (Exelon®), and galantamine (Reminyl®) — may temporarily improve or stabilize memory and thinking skills in some individuals.
    8 : Concern about Alzheimer Disease Time Magazine
    9 : Concern about Alzheimer Disease Progression of disease is unique Robs individual of identity and consciousness Causes displacement between mind and body A characteristic that differs from most other disease Initially the mind weakens while the body remains intact As population ages, incidence of the disease is increasing The disease is incurable Emotional and financial burden for families
    10 : Causes of Death Percentage Changes in Selected Causes of Death 2000 - 2010 Of the six major causes of death, only AD has increased.
    11 : Alzheimer and August D 1906 1906 1970
    12 : Early Years of Discovery Alois Alzheimer describes single case of August D in 1906 Advancements in technology are developed- histological stain Emil Kraeplin Colleague of Alzheimer and founder of modern psychiatry Psychiatric disease has a biological basis Discovered pathologic basis for Alzheimer Disease
    13 : Modern Understanding The work of Tomlinson and Roth in the 70’s informs modern understanding of AD Conducted systematic study Observed institutionalized patients Studied the brains of normal and demented subjects Saw huge differences between the two
    14 : Linked to Aging Proportion of People Aged 65 and Older with AD and Other Dementias by Race/Ethnicity Older African-Americans are about twice as likely, and Hispanics are about one and one-half times as likely to have AD and other dementias as older whites.
    15 : Changes of the Brain alz.org
    16 : Primary research approach of the past 15 years Focus on Amyloid Beta and removing pathology of disease 20+ failed trials related to removing plaques – removal causes vascular problems
    17 : The Focus of My Research Aging process Alzheimer affects one in every eight people 65 and older. Oxidative stress = damaging process Free radicals Why are increased free radicals in Alzheimer disease? How do brain cells respond? Role of antioxidants in slowing/delaying the aging process?
    18 : Where Do We Go From Here? Requires understanding the biology of aging Lifestyle modification has substantial benefit Improved care for patients Better quality of life Improvement in diagnosis If we can delay onset by five years, we reduce the disease by half!

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